How long does Prednisone stay in your system?

Every medicine needs a certain time frame to bring about any change in your body. In the same way, every medicine stays in your system for a certain period of time. Some of them may leave your system in a few hours or in a day or two. The time a medicine takes to leave your body depends upon a number of factors which may expedite or impede its excretion from your body.

Prednisone is a famous drug when it comes to treatment of medical conditions like arthritis, breathing problems, skin diseases, severe allergies, and immune system disorders. Your doctor might prescribe it for a number of other issues with a combination of an additional salt. Common side effects of this medicine include vomiting, nausea, loss of appetite, insomnia, and rashes. Remember to consult your doctor if any of these side effects persist or get worse. It is important to understand that the time taken for the drug to leave your circulatory system does not mean that you will get over the aftereffects of the medicine at the same time.

In this article, we will discuss the time Prednisone (prednisolone) stays in your body after you have stopped consuming it. We will also highlight the factors that impact the time taken by Prednisone to leave your body and how can you make sure that it is excreted from your body without any delays.

How long does Prednisone stay in your System?

In order to define the time taken for any medicine to leave your body, it is essential to clear the concept of half-life. Half-life is the time required by 50% of the drug to leave your body. After going through a lot of health journals and researches associated with Prednisone, we have arrived at the conclusion that theoretically; the half-life is Prednisone is around 2-3 hours in normal adults. Relying on the theoretical data, Prednisone will leave your system in 12-18 hours completely. Documented data, however, is not always correct, both Prednisone and Prednisolone (the metabolic form of Prednisone) may take up to 24 hours to leave your system completely. Aged people and children may exhibit differences in the time required for Prednisone to leave their system.

A lot of people are of the view that once Prednisone is out of their system, the side effects are also out of their system. This view is not correct. Medications like Prednisone impact human anatomy in many ways and the side effects continue to haunt you for a longer period of time.

Factors affecting the time taken for Prednisone to leave your system

A number of factors affect the time Prednisone takes to leave your system. These factors are given below

  • Dosage – The quantity you take is directly proportional to the time needed by the medicine to leave your system. Someone taking higher doses of Prednisone will have a higher quantity of its metabolites in the body after half-life time. People who have liver or kidney problems and are taking a high dose of Prednisone dose are prone to drug accumulation in their system.
  • Age – Age is a major factor when it comes to determining the time a medicine takes to leave your body. For people over the age of 65, a longer period of time is needed for Prednisone to leave their body because of the slow working of the organs that help in excreting the Prednisone. In the same way, children exhibit a slow clearance speed for Prednisone because it has an average half-life of 3-4 hours in children as compared to the normal half-life of 2-3 hours in healthy adults (below 65).
  • Liver and kidney function – Liver and kidneys are the two most vital organs in your body, impacting almost every function of the body and ensure timely excretion of the drugs. Researches have shown that people having liver and kidney problems take a longer time to get free of Prednisone in their blood. Tests have revealed that people with weak liver can take up to 3-4 days to get Prednisone free.
  • Build of your body – Body composition directly affects the time taken by Prednisone to leave the body. Tests conducted on people with different body height and weight have proved that Prednisone take less time to excrete in individuals with high body mass as compared to people with less body mass.
  • Metabolic Rate – Metabolic rate directly impacts the time a medicine takes to leave your body. If you have a high metabolic rate you will discharge Prednisone from your system faster as compared to people with a slow metabolic rate.
  • pH of the UrinepH of your urine directly impacts the excretion time of Prednisone. Alkaline pH of urine allows re-absorption of substances like Prednisone whereas acidic composition facilitates its discharge through urine.
  • Prescription Time – Accumulation of Prednisone in your system depends upon the time you have been prescribed the drug. It is very likely that it will be deposited in your system in a large quantity if you have been taking it for a longer period of time. Hence, the time needed to excrete it from your system will be more. Frequently taking Prednisone will develop a constant quantity of its metabolites in your body. On the contrary, if you take it for a short time, you will not reach the peak level of accumulation.
  • Other Medication – If you are taking other medications along with Prednisone, then you might witness extended time to discharge it from your system. Women taking oral contraceptive pills have to bear Prednisone in their circulation for a longer period of time.

How to get rid of Prednisone at earliest

If you want to make sure that Prednisone leaves your system as early as possible, there are some ways you can facilitate this process. Make sure that you discontinue this medicine under observation of your doctor. You can also acidify your urine by having drinks that are slightly acidic in nature or simply staying hydrated. Staying hydrated increases the number of times you urinate in a day.


The clearance time of Prednisone may vary from one person to another depending upon the factors explained above. However, it will leave your system within  16-24 hours . It is usually excreted from your body through urine, sweat, and breast milk for lactating mothers. Try to follow the instructions of your health practitioners, so you can treat the problem first for which the medicine is prescribed and then move towards excretion of its after effects.

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